Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in 1 diabetic rat heart
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چکیده
Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in 1 diabetic rat heart 2 3 Toan Pham, Denis Loiselle , Amelia Power and Anthony J.R Hickey 4 School of Biological Sciences the University of Auckland 5 Faculty of Medical and Health Sciences and Auckland Bioengineering Institute, the University of 6 Auckland 7 Corresponding author Dr Anthony Hickey, email: [email protected] 8 Postal address: Thomas Building, 3 a Symonds Street, Applied Surgery and Metabolism, School of 9 Biological Sciences, University of Auckland, New Zealand, 10 Running title: Diabetic heart mitochondrial efficiency 11 Articles in PresS. Am J Physiol Cell Physiol (June 11, 2014). doi:10.1152/ajpcell.00006.2014
منابع مشابه
Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart.
As ~80% of diabetic patients die from heart failure, an understanding of diabetic cardiomyopathy is crucial. Mitochondria occupy 35-40% of the mammalian cardiomyocyte volume and supply 95% of the heart's ATP, and diabetic heart mitochondria show impaired structure, arrangement, and function. We predict that bioenergetic inefficiencies are present in diabetic heart mitochondria; therefore, we ex...
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متن کاملThe effect of 6-deoxyclitoriacetal from Clitoria macrophylla Wall. on rat liver mitochondrial respiration and ATPase activity
A Thai plant Clitoria macrophylla Wall. was claimed to possess some pharmacological activities. The phytochemical studies reported a rotenoid compound, 6-deoxyclitoriacetal, which exhibits the cytotoxic effect in several cell line experiments. This report was to study the effect of 6-deoxyclitoriacetal on rat liver mitochondria, which may associated to its cytotoxic phenomena. Mitochondrial sus...
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